Madness has struck the vampires of Guild City. Is it a virus? Is it magic? No one knows. Fear of the unknown takes hold and causes chaos, escalating tensions between the vampires and humans.

After being presumed dead for two years, Lillas Mikkinnan returns to Guild City, bringing with her a new friend of a new species. Her unconventional methods of problem-solving may make the problem bigger, but she will solve the problem and that's all anyone needs to focus on.

Lillas isn't the only one with new friends and a new mission. Isadora Castor returns, bringing 99 problems and an interest in the Blackout. But why? What are she, Henri, and Eddie doing to it? Is their meddling causing the vampires to lose their minds? Letting Izzy live was Kratt's idea and Lillas will never let him live it down.