When Col. Quaritch set out to battle the Na'vi, he didn't expect to die, let alone wake up, "blue." He's been turned into a recombinant, a resurrected soldier hybridized with the indigenous of Pandora, a moon mankind wants for a second Earth. Dubbed, 'Humanity's Last Hope,' Quaritch and his Deja Blu team are tasked with protecting the people, but Quartich wants to hunt Jake Sully, the avatar driver who betrayed him to join the Na'vi fifteen years prior.

Jake, now a father and leader of the Omatikaya, desperately protects his own from the colonel and none more so than his adopted daughter, Kiri, whose delicate and mysterious nature leaves her the most vulnerable; however, trouble brews to dangerous levels when Kiri's closest friend, Spider, a human orphan, is thrown into the mix.

Not even Quaritch is immune from the dangers that threaten Sully as he, too, finds himself fighting for the same thing?family.