In this book, the Mechatronic System Model (MSM) approach is enhanced by the usage of Design Structure Matrices (DSM) as an alternative to SysML along with a strategy regarding the documentation and propagation of assumptions to better identify the ideal iteration return points. These aforementioned adaptations have been applied in a design study of an antibruxism device. In addition, the adaptations to the MSM approach have been tested in design experiments with two different design tasks. The first task was a redesign of a robot with two different system representations. The second task was to iteratively find a successful solution for a Moon lander simulation.